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CD49b (Integrin alpha 2) Mouse anti-Human, APC, Clone: P1H5, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $419.05

Specifications

Antigen CD49b (Integrin alpha 2)
Clone P1H5
Host Species Mouse
Gene Alias ITGA2, VLA-2, ECMR II
Species Reactivity Human
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014997

 
affymetrix
17050041
25 tests Each for $143.55

5014998

 
affymetrix
17050042
100 tests Each for $419.05
Description & Specifications

Specifications

Antigen CD49b (Integrin alpha 2)
Clone P1H5
Host Species Mouse
Gene Alias ITGA2, VLA-2, ECMR II
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This P1H5 monoclonal antibody reacts with human CD49b, which is also known as integrin alpha 2. Integrins constitute a family of cell surface receptors that mediate adhesion between cells or between a cell and the extracellular matrix. These proteins are heterodimers consisting of two distinct subunits, alpha and beta. Integrins are expressed on hematopoietic, non-hematopoietic, and cancer cells. Integrin-mediated adhesion is regulated by changes in ligand affinity (or activation), cell shape, and integrin clustering and diffusion. Integrin alpha 2 forms a complex with the common beta 1 subunit to form the alpha2beta1 integrin, which binds type I collagen and laminin. Moreover, studies suggest that this complex suppresses metastasis in cancer and participates in T cell costimulation by activating the MAPK and PI3K pathways.

The P1H5 monoclonal antibody has been reported to inhibit adhesion of fibroblasts and platelets to collagen. Crossblocking studies indicate that P1H5 and eBioY418 recognize different epitopes.