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CD48 Armenian Hamster anti-Mouse, APC-eFluor 780, Clone: HM48-1, eBioscience™

Armenian Hamster Monoclonal Antibody

$172.55 - $448.05

Specifications

Antigen CD48
Clone HM48-1
Host Species Armenian Hamster
Gene Alias BCM1, B-cell membrane protein, SLAMF2, BLAST1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124033

 
affymetrix
47048180
25μg Each for $172.55

501124034

 
affymetrix
47048182
100μg Each for $448.05
Description & Specifications

Specifications

Antigen CD48
Clone HM48-1
Host Species Armenian Hamster
Gene Alias BCM1, B-cell membrane protein, SLAMF2, BLAST1
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC-eFluor 780
Format Purified
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The HM48-1 monoclonal antibody reacts with the mouse CD48 antigen; also known as BCM1, Blast-1 (human), and OX-45 (rat). CD48, a member of the SLAM family and Ig superfamily, is a 45kDa GPI-linked glycoprotein expressed on the majority of hematopoietic cells. Recent publications have reported differential expression of members of the SLAM family including CD48, CD150, and CD244 among functionally distinct bone marrow hematopoietic progenitors providing a useful tool for prediction of the primitiveness of hematopoietic progenitors based on the expression of these SLAM family members. Hematopoietic stem cells (HSC) are highly purified as CD150(+)CD244(-)CD48(-) cells while non-self-renewing multipotent hematopoietic progenitors (MPP) are CD244(+)CD150(-)CD48(-) and the most restricted progenitors are CD48(+)CD244(+)CD150(-). CD48 plays a critical role in adhesion and T cell activation. In the mouse, the primary counter-receptors for CD48 are CD2 and CD244. HM48-1 is reported to modulate in vitro and in vivo CD48 functions including blocking the CD48/CD2 and CD48/CD244 interactions, inhibiting the proliferative response of mitogen-activated spleen cells, providing a costimulation signal for T cells activated in vitro through their TCR, and prolonging cardiac allograft survival in vivo.