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No crossreactivity is seen against human CD47.Description & Specifications
DescriptionThe monoclonal antibody miap301 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a glycosylated five transmembrane protein with a small cytoplasmic domain. CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with ß3 integrins CD51/CD61, CD41/CD61. It is also known to be the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Expression is found in the majority of hematopoietic cells including T and B cells, monocytes, platelets and erythrocytes (as part of the Rh complex). Expression is also found in non-hematopoietic cells.
No crossreactivity is seen against human CD47.
|Flow Cytometry,Immunohistochemistry (Frozen),Immunoprecipitation,Western Blot|
|Store at 2-8°C.|
|Integrin associated protein, IAP|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|