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CD47 Mouse anti-Human, Clone: B6H12, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

$130.68 - $473.88

Specifications

Antigen CD47
Clone B6H12
Host Species Murine
Gene Alias Integrin associated protein, IAP
Applications Flow Cytometry,Functional Assay
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5014326 Life Technologies
LS16047981
50μg Each for $130.68
5014327 Life Technologies
LS16047985
500μg Each for $473.88
Specifications

Description

The monoclonal antibody B6H12 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a glycosylated five transmembrane protein with a small alternatively spliced cytoplasmic domain. CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with β3 integrins CD51/CD61 and CD41/CD61. Furthermore this interaction can mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages. CD47 is the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Recently stimulation of CD47 by monoclonal antibody has been shown to induce CD4+CD25- suppressive activity also increasing expression of Foxp3. Expression is found in the majority of hematopoietic cells including T and B cells, monocytes, platelets and erythrocytes (as part of the Rh complex). Expression is also found in non-hematopoietic cells.

This antibody has been reported to have neutralizing activity.
Description & Specifications

Specifications

CD47
Murine
Flow Cytometry,Functional Assay
Unlabeled
Store at 2-8°C.
Monoclonal
1mg/mL
B6H12
Integrin associated protein, IAP
RUO
Purified
Primary
aqueous buffer, no sodium azide