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CD43 Rat anti-Mouse, PE, Clone: eBioR2/60, eBioscience™

Rat Monoclonal Antibody

$143.55 - $419.05

Specifications

Antigen CD43
Clone eBioR2/60
Host Species Rat
Gene Alias Leukosialin, LSN, Sialophorin, SPN
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010361

 
affymetrix
12043181
50μg Each for $143.55

5010362

 
affymetrix
12043182
100μg Each for $274.05

5010363

 
affymetrix
12043183
200μg Each for $419.05
Description & Specifications

Specifications

Antigen CD43
Clone eBioR2/60
Host Species Rat
Gene Alias Leukosialin, LSN, Sialophorin, SPN
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The eBioR2/60 monoclonal antibody reacts with mouse CD43, also known as leukosialin and sialophorin. CD43 has glycoforms of approximately 115 and 130 kDa, and is expressed by an early B cell subset in BM, thymocytes and mature T cells, NK cells, myeloid lineage cells and platelets. CD43 is reported to bind to CD54 and play a role in adhesion and B cell survival.

While the S7 and 1B11 monoclonal antibody clones detect only certain isoforms of CD43, data suggests that R2/60 detects the expression of both isoforms. It has been demonstrated that R2/60 stains the majority of CD4+ and CD8+ splenocytes, as well as a significant population of CD19+ splenocytes. However, the clones S7 and 1B11 stain only CD4+ and CD8+, or CD19+ splenocytes, respectively. This suggests that S7 and 1B11 recognize distinct epitopes which are differentially expressed by splenic B and T cells, whereas R2/60 recognizes an epitope shared by both isoforms of CD43.