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CD41 Rat anti-Mouse, PE-Cy7, Clone: eBioMWReg30 (MWReg30), eBioscience™

Rat Monoclonal Antibody

$114.55 - $404.55

Specifications

Antigen CD41
Clone eBioMWReg30 (MWReg30)
Host Species Rat
Gene Alias fibrinogen receptor, gpIIb/IIIa, integrin alpha Iib
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015509

 
affymetrix
25041180
25μg Each for $114.55

5015510

 
affymetrix
25041182
100μg Each for $404.55
Description & Specifications

Specifications

Antigen CD41
Clone eBioMWReg30 (MWReg30)
Host Species Rat
Gene Alias fibrinogen receptor, gpIIb/IIIa, integrin alpha Iib
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.

Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.