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CD41 Rat anti-Mouse, eFluor 450, Clone: eBioMWReg30 (MWReg30), eBioscience™

Rat Monoclonal Antibody

$187.44 - $376.20

Specifications

Antigen CD41
Clone eBioMWReg30 (MWReg30)
Host Species Rat
Gene Alias fibrinogen receptor, gpIIb/IIIa, integrin alpha Iib, ITGA2b
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5016288 Life Technologies
LS48041180
25μg Each for $187.44
5016289 Life Technologies
LS48041182
100μg Each for $376.20
Specifications

Description

The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.

Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.
Description & Specifications

Specifications

CD41
Rat
Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
eBioMWReg30 (MWReg30)
fibrinogen receptor, gpIIb/IIIa, integrin alpha Iib, ITGA2b
Flow Cytometry
eFluor 450
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL