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CD40 Rat anti-Mouse, Clone: 1C10, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$114.55 - $796.05

Specifications

Antigen CD40
Clone 1C10
Host Species Rat
Gene Alias TNFRSF5
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014300

 
affymetrix
16040182
100μg Each for $230.55

5014299

 
affymetrix
16040181
50μg Each for $114.55

5014301

 
affymetrix
16040185
500μg Each for $404.55

501129532

 
affymetrix
16-0401-86
1mg Each for $796.05
Description & Specifications

Specifications

Antigen CD40
Clone 1C10
Host Species Rat
Gene Alias TNFRSF5
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

The monoclonal antibody 1C10 is reported to have agonistic activity in vitro and in vivo.