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CD40, APC, clone: 5C3, eBioscience™

Mouse Monoclonal Antibody

Manufacturer:  Life Technologies LS17040941

 View more versions of this product

Catalog No. 501129476



Description

Description

The CD40 antigen is a single chain glycoprotein. It is known to be a member of the tumor necrosis factor / nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells. It is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. The precise function of the CD40 antigen is unknown but it appears to be involved in the transduction of regulatory signals for cellular functions such as B cell proliferation and differentiation.

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin′s disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
Specifications

Specifications

CD40
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P25942
Bp50, CDW40, MGC9013, TNFRSF5, p50
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
5C3
APC
CD40
Liquid
CD40
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
958
Documents

For Research Use Only.