Please login to your online account to display your discounted pricing

CD370 (Clec9A) Rat anti-Mouse, PE, Clone: 42D2, eBioscience™

Rat Monoclonal Antibody

$143.55 - $404.55

Specifications

Antigen CD370 (Clec9A)
Clone 42D2
Host Species Rat
Gene Alias DNGR-1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011043

 
affymetrix
12-5975-80
25μg Each for $143.55

5011044

 
affymetrix
12597582
100μg Each for $404.55
Description & Specifications

Specifications

Antigen CD370 (Clec9A)
Clone 42D2
Host Species Rat
Gene Alias DNGR-1
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This 42D2 monoclonal antibody reacts with mouse CD370, which is also known as DNGR-1 or Clec9A. CD370 is a C-type lectin-like receptor expressed on conventional and plasmacytoid dendritic cells (DCs). In particular, CD8+ conventional DCs in the thymus, spleen, and lymph nodes, as well as CD24+ DCs in the blood, express CD370. This receptor is not detectable on most B cells, T and NK cells, monocytes, and macrophages. The cytoplasmic domain of CD370 contains an ITAM motif that has been demonstrated to phosphorylate Syk tyrosine kinase, leading to NFAT activation. This signaling reportedly mediates the presentation of necrotic cell-associated antigens by CD8+ DCs in innate immunity.