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CD369 (Clec7A, Dectin-1) Rat anti-Mouse, PE, Clone: bg1fpj, eBioscience™

Rat Monoclonal Antibody

$158.05 - $433.55

Specifications

Antigen CD369 (Clec7A, Dectin-1)
Clone bg1fpj
Host Species Rat
Gene Alias Beta-glucan receptor, ClecSF12
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122337

 
affymetrix
12585980
25μg Each for $158.05

501122338

 
affymetrix
12585982
100μg Each for $433.55
Description & Specifications

Specifications

Antigen CD369 (Clec7A, Dectin-1)
Clone bg1fpj
Host Species Rat
Gene Alias Beta-glucan receptor, ClecSF12
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody bg1fpj recognizes mouse CD369, also known as Dectin-1 or CLEC7A, a type II transmembrane protein in the C-type lectin family. The ligand is beta1, 3-glycan. Beta glycans are a main component in polysaccharides and specifically beta1,3-linked carbohydrates are found in the cell wall of fungi, plants and some bacteria. CD369 has been found to bind Candida, Aspergillis, Pneumocystis, Coccidioides and Mycobacterium. Calcium dependent binding to ligand signals through syk via the ITAM domain in the cytoplasmic portion and results in endocyotosis/phagocytosis and production of cytokines (IL-2, IL-6, IL-10, TNF alpha, IL-1 beta, IL-23). A direct role in Th17 and Th1 differentiation has been attributed to CD369 signaling. CD369 is expressed predominantly on myeloid cells (neutrophils, monocytes, macrophages, and dendritic cells). Low levels have also been reported on lymphocytes and mucosal epithelium.