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CD369 (Clec7A, Dectin-1) Mouse anti-Human, Non-human primate, Clone: 15E2, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

$274.05 - $462.55

Specifications

Antigen CD369 (Clec7A, Dectin-1)
Clone 1.50E+03
Host Species Mouse
Gene Alias Beta-glucan receptor, CLEC7A
Species Reactivity Human, Non-human primate
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123011

 
affymetrix
16985682
100μg Each for $274.05

501123012

 
affymetrix
16985685
500μg Each for $462.55
Description & Specifications

Specifications

Antigen CD369 (Clec7A, Dectin-1)
Clone 1.50E+03
Host Species Mouse
Gene Alias Beta-glucan receptor, CLEC7A
Species Reactivity Human, Non-human primate
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

This 15E2 monoclonal antibody reacts with human and non-human primate CD369, which is also known as the Dectin-1 or beta-glucan receptor or CLEC7A. CD369 is expressed predominantly on monocytes, macrophages, and dendritic cells. Moreover, this receptor can also be detected on neutrophils and lymphocytes, as well as induced by cytokines such as IL-4 or LPS. In humans, CD369 exists as two isoforms that arise due to alternative splicing. CD369 binds beta-1,3-glucan and plays an important role in activating signal transduction involved in the innate immune response to fungal and mycobacterial infections. Studies have also shown the involvement of CD369 in dendritic cell activation.

The 15E2 monoclonal antibody has been reported to recognize both isoforms of CD369 and activate dendritic cells. It does not crossreact to mouse CD369.