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CD366 (TIM3) Mouse anti-Human, eFluor 450, Clone: F38-2E2, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $448.05

Specifications

Antigen CD366 (TIM3)
Clone F38-2E2
Host Species Mouse
Gene Alias HAVCR2, T cell immunoglobulin and mucin domain-containing protein 3
Species Reactivity Human
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124153

 
affymetrix
48310941
25 tests Each for $172.55

501124154

 
affymetrix
48310942
100 tests Each for $448.05
Description & Specifications

Specifications

Antigen CD366 (TIM3)
Clone F38-2E2
Host Species Mouse
Gene Alias HAVCR2, T cell immunoglobulin and mucin domain-containing protein 3
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 450
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test

This F38-2E2 monoclonal antibody reacts with human CD366, also known as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) or HAVCR2. This cell surface receptor is expressed on activated CD4+ T cell subsets (e.g. Th1, Th17, and Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells. Due to alternative splicing, CD366 exists as membrane-bound and soluble forms. Galectin-9 has been identified as the ligand for CD366. In humans, this receptor negatively regulates CD4+ T cells, influencing the secretion of some Th1- and Th17-related cytokines. CD366 has also been implicated in tolerance, autoimmune disease (e.g. multiple sclerosis), and HIV infection.