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CD357 (GITR) Rat anti-Mouse, eFluor 450, Clone: DTA-1, eBioscience™

Rat Monoclonal Antibody

$201.55 - $404.55

Specifications

Antigen CD357 (GITR)
Clone DTA-1
Host Species Rat
Gene Alias TNFRSF18, AITR, glucocorticoid-induced TNFR-related
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5016377

 
affymetrix
48587480
25μg Each for $201.55

5016378

 
affymetrix
48587482
100μg Each for $404.55
Description & Specifications

Specifications

Antigen CD357 (GITR)
Clone DTA-1
Host Species Rat
Gene Alias TNFRSF18, AITR, glucocorticoid-induced TNFR-related
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 450
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.