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CD357 (GITR) Rat anti-Mouse, Clone: DTA-1, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$201.55 - $549.55

Specifications

Antigen CD357 (GITR)
Clone DTA-1
Host Species Rat
Gene Alias TNFRSF18, AITR, glucocorticoid-induced TNFR-related
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122962

 
affymetrix
16587483
200μg Each for $549.55

5014587

 
affymetrix
16587481
50μg Each for $201.55
Description & Specifications

Specifications

Antigen CD357 (GITR)
Clone DTA-1
Host Species Rat
Gene Alias TNFRSF18, AITR, glucocorticoid-induced TNFR-related
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.