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CD35 Mouse anti-Human, Non-human primate, FITC, Clone: E11, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $288.55

Specifications

Antigen CD35
Clone E11
Host Species Mouse
Gene Alias Complement receptor 1, CR1, C3b/C4b receptor
Species Reactivity Human, Non-human primate
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245232

 
affymetrix
11035941
25 tests Each for $129.05

50245233

 
affymetrix
11035942
100 tests Each for $288.55
Description & Specifications

Specifications

Antigen CD35
Clone E11
Host Species Mouse
Gene Alias Complement receptor 1, CR1, C3b/C4b receptor
Species Reactivity Human, Non-human primate
Applications Flow Cytometry
Regulatory Status RUO
Conjugate FITC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

This E11 monoclonal antibody reacts with human and non-human primate CD35, which is also known as complement receptor 1 (CR1). CD35 is expressed on B cells, T cell subsets, follicular dendritic cells, macrophages, neutrophils, eosinophils, and erythrocytes. This cell surface protein is also present on non-immune cells such as glomerular podocytes and Langerhans cells. CD35 binds the complement components C3b and C4b, which are derived from cleavage of C3 and C4, respectively, in the classical and alternative complement pathways. In humans, CD35 has been implicated in a variety of roles, including complement activation, transporting C3 complexes on erythrocytes, phagocytosis of complement-bound neutrophils and macrophages, B cell proliferation, and opsonization. Reports also indicate that Plasmodium falciparum, the pathogen that causes malaria, invades host erythrocytes by binding CD35. Decreased expression of CD35 on erythrocytes has been associated with systemic lupus erythematosus (SLE), type I diabetes, and rheumatoid arthritis.

The E11 antibody has been reported to crossreact to capuchin monkey, chimpanzee, cynomologus monkey, olive baboon, and rhesus macaque.