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CD336 (NKp44) Mouse anti-Human, Clone: 44.189, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

$274.05 - $578.55

Specifications

Antigen CD336 (NKp44)
Clone 44.189
Host Species Mouse
Gene Alias NCR2
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122956

 
affymetrix
16336982
100μg Each for $274.05

501122957

 
affymetrix
16336985
500μg Each for $578.55
Description & Specifications

Specifications

Antigen CD336 (NKp44)
Clone 44.189
Host Species Mouse
Gene Alias NCR2
Species Reactivity Human
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The monoclonal antibody 44.189 reacts with human CD336, which is also known as NKp44 or NCR2. CD336 is a 44kDa transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family and contains an ITIM domain located in the cytoplasmic tail. Expression of CD336 and NK cell activation by the receptor requires association with DAP12, an ITAM-containing transmembrane accessory protein. Once thought to be expressed exclusively on IL-2-activated NK cells and a subset of gamma delta T lymphocytes, studies have shown expression of CD336 on IL-3-stimulated plasmacytoid dendritic cells, alpha beta T cells in the small intestinal epithelium, and T cells in cord blood. CD336 has been shown to be involved in the innate response of activated NK cells against viral infection and tumor cell proliferation.

The 44.189 antibody has been reported to facilitate CD336 crosslinking.