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CD335 (NKp46) Rat anti-Mouse, Clone: 29A1.4, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$216.05 - $535.05

Specifications

Antigen CD335 (NKp46)
Clone 29A1.4
Host Species Rat
Gene Alias NCR1, Ly-94
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014520

 
affymetrix
16-3351-81
50μg Each for $216.05

5014521

 
affymetrix
16-3351-85
500μg Each for $535.05
Description & Specifications

Specifications

Antigen CD335 (NKp46)
Clone 29A1.4
Host Species Rat
Gene Alias NCR1, Ly-94
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines.

The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo.