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CD324 (E-cadherin) Rat, Biotin, Clone: DECMA-1, eBioscience™

Rat Monoclonal Antibody

$143.88 - $341.88

Specifications

Antigen CD324 (E-cadherin)
Clone DECMA-1
Host Species Rat
Gene Alias epithelial cadherin
Species Reactivity Canine, Human, Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5011833 Life Technologies
LS13324980
25μg Each for $143.88
5011834 Life Technologies
LS13324982
100μg Each for $341.88
Specifications

Description

The monoclonal antibody DECMA-1 recognizes mouse, human and canine CD324 also known as E-cadherin (Epithelial cadherin) or uvomorulin. Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton.

Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the progression of a variety of cancers.

E-Cadherin protein is sensitive to trypsin treatment, so exposure to trypsin should be minimized or avoided.

The monoclonal antibody DECMA-1 has been shown to have functional activity by disrupting adhesion in human, mouse and dog cells.
Description & Specifications

Specifications

CD324 (E-cadherin)
Rat
Canine, Human, Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
DECMA-1
epithelial cadherin
Flow Cytometry,Immunohistochemistry (Frozen),Western Blot
Biotin
Store at 2-8°C. Do not freeze.
Monoclonal
0.5mg/mL