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CD324 (E-cadherin) Rat, Biotin, Clone: DECMA-1, eBioscience™

Rat Monoclonal Antibody

$158.05 - $375.55

Specifications

Antigen CD324 (E-cadherin)
Clone DECMA-1
Host Species Rat
Gene Alias epithelial cadherin
Species Reactivity Canine, Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011833

 
affymetrix
13324980
25μg Each for $158.05

5011834

 
affymetrix
13324982
100μg Each for $375.55
Description & Specifications

Specifications

Antigen CD324 (E-cadherin)
Clone DECMA-1
Host Species Rat
Gene Alias epithelial cadherin
Species Reactivity Canine, Human, Mouse
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Applications Western Blotting
Regulatory Status RUO
Conjugate Biotin
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody DECMA-1 recognizes mouse, human and canine CD324 also known as E-cadherin (Epithelial cadherin) or uvomorulin. Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton.

Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the progression of a variety of cancers.

E-Cadherin protein is sensitive to trypsin treatment, so exposure to trypsin should be minimized or avoided.

The monoclonal antibody DECMA-1 has been shown to have functional activity by disrupting adhesion in human, mouse and dog cells.