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CD317 (BST2/PDCA-1) Rat anti-Mouse, PE, Clone: eBio129c (129c), eBioscience™

Rat Monoclonal Antibody

$172.55 - $448.05

Specifications

Antigen CD317 (BST2/PDCA-1)
Clone eBio129c (129c)
Host Species Rat
Gene Alias plasmacytoid DC Ag-1, pDC Ag-1
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010750

 
affymetrix
12317181
50μg Each for $172.55

5010751

 
affymetrix
12317182
100μg Each for $448.05
Description & Specifications

Specifications

Antigen CD317 (BST2/PDCA-1)
Clone eBio129c (129c)
Host Species Rat
Gene Alias plasmacytoid DC Ag-1, pDC Ag-1
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The eBio129c monoclonal antibody reacts with mouse PDCA-1 (BST2, CD317), a specific marker of plasmacytoid dendritic cells (pDC), also known as type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPCs are typically CD11c+, CD11b-, B220+, Ly-6C+, and CD62L+. PDCA-1 is predominantly expressed by IPCs in the naïve mouse which represent sa very minor population (<0.5%) of splenocytes. It is upregulated on numerous cell types following stimulation which triggers an IFN response. PDCA-1 cycles between cell surface and intracellular compartments and may function to regulate trafficking of secreted cytokines. PDCA-1 (BST2) is the protein recognized by the antibody 120G8.

The epitope recognized by eBio129c is distinct from eBio927; thus, the antibodies can be used to costain, purify and identify pDCs.