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CD317 (BST2/PDCA-1) Rat anti-Mouse, Clone: eBio927, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$158.05 - $506.05

Specifications

Antigen CD317 (BST2/PDCA-1)
Clone eBio927
Host Species Rat
Gene Alias plasmacytoid DC Ag-1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014515

 
affymetrix
16-3172-81
50μg Each for $158.05

5014517

 
affymetrix
16317285
500μg Each for $506.05
Description & Specifications

Specifications

Antigen CD317 (BST2/PDCA-1)
Clone eBio927
Host Species Rat
Gene Alias plasmacytoid DC Ag-1
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The eBio927 monoclonal antibody reacts with PDCA-1 (BST2, CD317), a specific marker of plasmacytoid dendritic cells (pDC), also known as type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPCs are typically CD11c+, CD11b-, B220+, Ly-6C+, and CD62L+. PDCA-1 is predominantly expressed by IPCs in the naïve mouse which represents a very minor population (<0.5%) of splenocytes. It is upregulated on numerous cell types following stimulation which triggers an IFN response. PDCA-1 cycles between cell surface and intracellular compartments and may function to regulate trafficking of secreted cytokines. PDCA-1 (BST2) is the protein recognized by antibody 120G8.

The eBio927 monoclonal antibody has also been shown to have functional activity. The epitope recognized by eBio927 is distinct from eBio129c; thus, the antibodies can be used to costain, purify and identify pDCs.