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CD317 (BST2/PDCA-1) Rat anti-Mouse, APC, Clone: eBio927, eBioscience™

Rat Monoclonal Antibody

$143.55 - $433.55

Specifications

Antigen CD317 (BST2/PDCA-1)
Clone eBio927
Host Species Rat
Gene Alias plasmacytoid DC Ag-1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123122

 
affymetrix
17317280
25μg Each for $143.55

501128760

 
affymetrix
17-3172-82
100μg Each for $433.55
Description & Specifications

Specifications

Antigen CD317 (BST2/PDCA-1)
Clone eBio927
Host Species Rat
Gene Alias plasmacytoid DC Ag-1
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The eBio927 monoclonal antibody reacts with PDCA-1 (BST2, CD317), a specific marker of plasmacytoid dendritic cells (pDC), also known as type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPCs are typically CD11c+, CD11b-, B220+, Ly-6C+, and CD62L+. PDCA-1 is predominantly expressed by IPCs in the naïve mouse which represents a very minor population (<0.5%) of splenocytes. It is upregulated on numerous cell types following stimulation which triggers an IFN response. PDCA-1 cycles between cell surface and intracellular compartments and may function to regulate trafficking of secreted cytokines. PDCA-1 (BST2) is the protein recognized by antibody 120G8.

The eBio927 monoclonal antibody has also been shown to have functional activity. The epitope recognized by eBio927 is distinct from eBio129c; thus, the antibodies can be used to costain, purify and identify pDCs.