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CD314 (NKG2D) Mouse anti-Human, Clone: 1D11, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $288.55

Specifications

Antigen CD314 (NKG2D)
Clone 1D11
Host Species Mouse
Gene Alias KLRK1
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013255

 
affymetrix
14587882
100μg Each for $288.55

5013254

 
affymetrix
14587880
25μg Each for $143.55
Description & Specifications

Specifications

Antigen CD314 (NKG2D)
Clone 1D11
Host Species Mouse
Gene Alias KLRK1
Species Reactivity Human
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The 1D11 monoclonal antibody reacts with the human NKG2D, a 42kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.