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This 3DS304M antibody will recognize formaldehyde-fixed as well as methanol-treated epitopes.Description & Specifications
DescriptionThe monoclonal antibody 3DS304M recognizes mouse CD304 (Neuropilin-1), a type 1 transmembrane glycoprotein present on the surface of multiple cell types, including: regulatory T cells (Treg), NKT cells, DC, certain types of stem cells, neurons, endothelial cells, and some neoplastic cells. Neuropilin-1, in complex with plexins, serves as a co-receptor for type 3 semaphorins in growing neurons. It is also involved in the process of angiogenesis being a part of a functional receptor for VEGF in endothelial cells. In mice, Neuropilin-1 is expressed on thymus-derived natural Treg but not peripherally induced Treg. In addition, transient expression on recently activated non-regulatory T cells has been observed. Neuropilin-1 has been used as a marker of recent thymic emigrants in the mouse iNKT cell population. It has been shown that Neuropilin-1 forms a complex with TGF beta receptors, activating the latent form of TGF beta (LAP-TGF beta 1) and augmenting canonical Smad2/3 signaling.
This 3DS304M antibody will recognize formaldehyde-fixed as well as methanol-treated epitopes.
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|Nrp-1, NP-1, BDCA-4|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|