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CD300e (IREM-2) Mouse anti-Human, PE, Clone: UP-H2, eBioscience™

Mouse Monoclonal Antibody

$230.55 - $433.55

Specifications

Antigen CD300e (IREM-2)
Clone UP-H2
Host Species Mouse
Gene Alias IREM2, CLM-2
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010744

 
affymetrix
12300741
25 tests Each for $230.55

5010745

 
affymetrix
12300742
100 tests Each for $433.55
Description & Specifications

Specifications

Antigen CD300e (IREM-2)
Clone UP-H2
Host Species Mouse
Gene Alias IREM2, CLM-2
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test

The monoclonal antibody UP-H2 recognizes human IREM-2 (immune receptor expressed in monocytic derived cells) also known as LMIR6, and unofficially CD300E and CD300LE. It is a member of the CMRF-35 family. This 34kDa Ig-like containing receptor is an activating receptor and through it’s charged residues in the cytokplasmic domain interacts with ITAM containing adaptor proteins like DAP12. Expression is found exclusively on monocytes and myeloid DC’s. Expression may be transient as differentiation of monocytes leads to down regulation of IREM-2 yet expression is found on mature DCs. It has been also noted that myeloid cell lines such as THP-1 and U937 do not express IREM-2.
In vitro addition of UP-H2 antibody either soluble or crosslinked stimulates monocytes.