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CD284 (TLR4) Mouse anti-Human, Biotin, Clone: HTA125, eBioscience™

Mouse Monoclonal Antibody

$130.68 - $289.08

Specifications

Antigen CD284 (TLR4)
Clone HTA125
Host Species Murine
Gene Alias TLR-4, toll-like receptor 4
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5012260 Life Technologies
LS13991780
25μg Each for $130.68
5012261 Life Technologies
LS13991782
100μg Each for $289.08
Specifications

Description

The HTA125 monoclonal antibody reacts with human Toll-like receptor 4 (TLR4). So far, at least ten members of the Toll family have been identified in humans. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4 is expressed by peripheral blood monocytes. HTA125 has been reported to immunoprecipitate human TLR4 (∽100 kDa) from transfected cells. Most TLR cell surface expression, especially TLR1 and TLR4, occurs at low levels on monocytes and at even lower levels on other cell types including granulocytes and immature dendritic cells (iDC). Furthermore, a relatively high degree of variability in TLR surface expression has been reported among normal donors.
Description & Specifications

Specifications

CD284 (TLR4)
Murine
Flow Cytometry
Biotin
Store at 2-8°C. Do not freeze.
Monoclonal
0.5mg/mL
HTA125
TLR-4, toll-like receptor 4
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer