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CD283 (TLR3) Mouse anti-Human, PE, Clone: TLR3.7, eBioscience™

Mouse Monoclonal Antibody

$259.55 - $462.55

Specifications

Antigen CD283 (TLR3)
Clone TLR3.7
Host Species Mouse
Gene Alias TLR-3, toll-like receptor 3
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122415

 
affymetrix
12903982
100μg Each for $462.55

5011247

 
affymetrix
12903980
25μg Each for $259.55
Description & Specifications

Specifications

Antigen CD283 (TLR3)
Clone TLR3.7
Host Species Mouse
Gene Alias TLR-3, toll-like receptor 3
Species Reactivity Human
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The TLR3.7 monoclonal antibody reacts with human Toll-like receptor 3 (TLR3). To date, at least twelve members of the Toll-like receptor family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. In the innate immune response, TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial activity. TLR3 recognizes double-stranded (ds)RNA, induces the activation of NF-κB through MyD88-dependent and -independent pathways, and the production of type I interferons (IFNs). TLR3.7 suppressed poly(I):poly(C)-mediated IFN-β production by human fibroblasts naturally expressing TLR3 on their surface.