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CD281 (TLR1) Mouse anti-Human, Clone: GD2.F4, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $361.05

Specifications

Antigen CD281 (TLR1)
Clone GD2.F4
Host Species Murine
Gene Alias TLR-1, toll-like receptor 1
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013852 Life Technologies
LS14991180
25μg Each for $158.05
5013853 Life Technologies
LS14991182
100μg Each for $361.05
Specifications

Description

The GD2.F4 antibody reacts with human Toll-like receptor 1 (TLR1). TLR1 is expressed in low numbers on the surface of peripheral blood monocytes and even lower numbers on dendritic cells. A very high degree of donor variability has been reported for TLR1 expression. eBioscience manufactured GD2.F4 mAb has been tested by flow cytometry, in parallel with a sample from the developer using cells from healthy donors. eBioscience and the reference antibody gave similar results: donors tested confirmed low levels expression of TLR1 on PBMC (less than 1/4 log shift). While the ligand and exact function of TLR1 are not defined yet, it has been suggested that TLR1 may cooperate with TLR2 in response to certain antagonists. Despite low levels of surface expression as detected by flow cytometric analysis, TLRs are efficient signal transducing molecules in monocytes and dendritic cells. To date, at least ten members of the Toll family have been identified in human. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation.
Description & Specifications

Specifications

CD281 (TLR1)
Murine
Human
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
GD2.F4
TLR-1, toll-like receptor 1
Flow Cytometry,Immunohistochemistry
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL