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CD279 (PD-1) Mouse anti-Human, Clone: J121, eBioscience™

Mouse Monoclonal Antibody

$159.72 - $402.60

Specifications

Antigen CD279 (PD-1)
Clone J121
Host Species Murine
Applications Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122666 Life Technologies
LS14279880
25μg Each for $159.72
501122667 Life Technologies
LS14279882
100μg Each for $402.60
Specifications

Description

This J121 monoclonal antibody reacts with human CD279 (programmed death-1, PD-1), a 55kDa member of the CD28 immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the CD279 ligands, CD274 (PD-L1, B7-H1) and CD273 (PD-L2, B7-DC). Evidence reported to date suggests overlapping functions for these two ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. More recently, therapies targeting the blockade of the CD279/CD274 pathway have become the focus for treatment of melanoma, renal cell cancer, Hodgkins’ lymphoma, and non-small cell lung carcinoma (NSCLC).

The J121 monoclonal antibody is not recommended for flow cytometry of human cells. For detection of human CD279 using flow cytometry please refer to clone eBioJ105 (J105).
Description & Specifications

Specifications

CD279 (PD-1)
Murine
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
J121
Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL