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CD279 (PD-1) Mouse anti-Human, Clone: J121, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $433.55

Specifications

Antigen CD279 (PD-1)
Clone J121
Host Species Mouse
Species Reactivity Human
Applications Immunohistochemistry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122666

 
affymetrix
14279880
25μg Each for $172.55

501122667

 
affymetrix
14279882
100μg Each for $433.55
Description & Specifications

Specifications

Antigen CD279 (PD-1)
Clone J121
Host Species Mouse
Species Reactivity Human
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This J121 monoclonal antibody reacts with human CD279 (programmed death-1, PD-1), a 55kDa member of the CD28 immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the CD279 ligands, CD274 (PD-L1, B7-H1) and CD273 (PD-L2, B7-DC). Evidence reported to date suggests overlapping functions for these two ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. More recently, therapies targeting the blockade of the CD279/CD274 pathway have become the focus for treatment of melanoma, renal cell cancer, Hodgkins’ lymphoma, and non-small cell lung carcinoma (NSCLC).

The J121 monoclonal antibody is not recommended for flow cytometry of human cells. For detection of human CD279 using flow cytometry please refer to clone eBioJ105 (J105).