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CD279 (PD-1) Mouse anti-Human, Clone: J116, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

$143.88 - $2,506.68

Specifications

Antigen CD279 (PD-1)
Clone J116
Host Species Murine
Gene Alias PD1
Applications Functional Assay
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5014824 Life Technologies
LS16998980
25μg Each for $143.88
501129640 Life Technologies
LS16998982
100μg Each for $381.48
501129737 Life Technologies
LS16998938
5mg Each for $2,506.68
Specifications

Description

The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.
Description & Specifications

Specifications

CD279 (PD-1)
Murine
Functional Assay
Unlabeled
Store at 2-8°C.
Monoclonal
1mg/mL
J116
PD1
RUO
Purified
Primary
aqueous buffer, no sodium azide