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CD279 (PD-1) Mouse anti-Human, Clone: J116, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $216.05

Specifications

Antigen CD279 (PD-1)
Clone J116
Host Species Mouse
Gene Alias PD1
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013972

 
affymetrix
14998980
25μg Each for $143.55

501128748

 
affymetrix
14-9989-82
100μg Each for $216.05
Description & Specifications

Specifications

Antigen CD279 (PD-1)
Clone J116
Host Species Mouse
Gene Alias PD1
Species Reactivity Human
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.