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CD279 (PD-1) Mouse anti-Human, Clone: J116, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $216.05

Specifications

Antigen CD279 (PD-1)
Clone J116
Host Species Murine
Gene Alias PD1
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013972 Life Technologies
LS14998980
25μg Each for $143.55
501128748 Life Technologies
LS14998982
100μg Each for $216.05
Specifications

Description

The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.
Description & Specifications

Specifications

CD279 (PD-1)
Murine
Human
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
J116
PD1
Functional Assay,Immunohistochemistry (Frozen),Immunoprecipitation
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL