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CD279 (PD-1) Armenian Hamster anti-Mouse, Clone: J43, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

$158.05 - $477.05

Specifications

Antigen CD279 (PD-1)
Clone J43
Host Species Armenian Hamster
Gene Alias PD1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014821

 
affymetrix
16-9985-81
50μg Each for $158.05

5014822

 
affymetrix
16998582
100μg Each for $245.05

5014823

 
affymetrix
16998585
500μg Each for $477.05
Description & Specifications

Specifications

Antigen CD279 (PD-1)
Clone J43
Host Species Armenian Hamster
Gene Alias PD1
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.