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CD278 (ICOS) Mouse anti-Human, Clone: ISA-3, eBioscience™

Mouse Monoclonal Antibody

$143.88 - $328.68

Specifications

Antigen CD278 (ICOS)
Clone ISA-3
Host Species Murine
Species Reactivity Human
Applications Flow Cytometry,Functional Assay,Immunohistochemistry (Frozen),Immunoprecipitation
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013909 Life Technologies
LS14994880
25μg Each for $143.88
5013910 Life Technologies
LS14994882
100μg Each for $328.68
Specifications

Description

The ISA-3 monoclonal antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. Human ICOS has a relative molecular mass of 55-60 kDa, composed of 27kDa and 29kDa chains. Human ICOS on activated T cells has potent costimulatory activity for T cell activation and is required for humoral immune responses, in particular for memory B cell and plasma cell generation. ICOS binds to its ligand, B7h/B7RP-1 expressed on activated APCs (antigen presenting cells) and on a number of inflamed peripheral tissues. Plate-bound ISA-3 is costimulatory for T cells and induces production of IL-4, IL-5, IL-10 and other cytokines, but not IL-2. ISA-3 has the same reactivity pattern and characteristics as F44. ISA-3 was generated against the human ICOS antigen. C398.4A, anti-mouse ICOS/H4 (cat. 14-9949), was shown to cross-react with human ICOS but binds to an epitope different from ISA-3. C398.4A stains activated cells brighter than ISA-3; however, it also exhibits higher staining of non-activated human peripheral blood or isolated PBMC. To achieve the brightest staining of ICOS on activated human T cells, please use 13-9948 or 12-9948 rather than 11-9948.
Description & Specifications

Specifications

CD278 (ICOS)
Murine
Flow Cytometry,Functional Assay,Immunohistochemistry (Frozen),Immunoprecipitation
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
ISA-3
Human
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer