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CD278 (ICOS) Armenian Hamster anti-Mouse, Rat, PE-Cy7, Clone: C398.4A, eBioscience™

Armenian Hamster Monoclonal Antibody

$158.05 - $390.05

Specifications

Antigen CD278 (ICOS)
Clone C398.4A
Host Species Armenian Hamster
Gene Alias Inducible T-cell COStimulator
Species Reactivity Mouse, Rat
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123476

 
affymetrix
25994980
25μg Each for $158.05

501123477

 
affymetrix
25994982
100μg Each for $390.05
Description & Specifications

Specifications

Antigen CD278 (ICOS)
Clone C398.4A
Host Species Armenian Hamster
Gene Alias Inducible T-cell COStimulator
Species Reactivity Mouse, Rat
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).