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CD278 (ICOS) Armenian Hamster anti-Mouse, Rat, PE-Cy5, Clone: C398.4A, eBioscience™

Armenian Hamster Monoclonal Antibody

$129.05 - $390.05

Specifications

Antigen CD278 (ICOS)
Clone C398.4A
Host Species Armenian Hamster
Species Reactivity Mouse, Rat
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5014158 Life Technologies
LS15994981
50μg Each for $129.05
5014159 Life Technologies
LS15994982
100μg Each for $390.05
Specifications

Description

The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).
Description & Specifications

Specifications

CD278 (ICOS)
Armenian Hamster
Flow Cytometry
PE-Cy5
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
C398.4A
Mouse, Rat
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer