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CD278 (ICOS) Armenian Hamster anti-Mouse, Rat, PE-Cy5, Clone: C398.4A, eBioscience™

Armenian Hamster Monoclonal Antibody

$129.05 - $390.05

Specifications

Antigen CD278 (ICOS)
Clone C398.4A
Host Species Armenian Hamster
Species Reactivity Mouse, Rat
Applications Flow Cytometry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014158

 
affymetrix
15-9949-81
50μg Each for $129.05

5014159

 
affymetrix
15-9949-82
100μg Each for $390.05
Description & Specifications

Specifications

Antigen CD278 (ICOS)
Clone C398.4A
Host Species Armenian Hamster
Species Reactivity Mouse, Rat
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy5
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).