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CD276 (B7-H3) Mouse anti-Human, PE-Cyanine7, Clone: 7-517, eBioscience™

Mouse Monoclonal Antibody

Manufacturer:  Life Technologies LS25276942

Catalog No. 501129252



Description

Description

Description: This 7-517 monoclonal antibody reacts with human CD276, which is also known as B7-H3. This type I transmembrane protein is expressed on immature and mature dendritic cells but not monocytes, granulocytes, or resting lymphocytes. Moreover, CD2

00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
Specifications

Specifications

CD276 (B7-H3)
Monoclonal
5 μL/Test
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Q5ZPR3
PSEC0249, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, B7 homolog 3, CD276 antigen, costimulatory molecule
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
7-517
PE-Cyanine7
CD276
Liquid
CD276
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
80381
Documents

For Research Use Only.