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CD273 (B7-DC) Rat anti-Mouse, PE, Clone: TY25, eBioscience™

Rat Monoclonal Antibody

$187.05 - $462.55

Specifications

Antigen CD273 (B7-DC)
Clone TY25
Host Species Rat
Gene Alias B7DC, PD-L2, PDL-2, PDL2
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011059

 
affymetrix
12598681
50μg Each for $187.05

5011061

 
affymetrix
12598683
200μg Each for $462.55

501129371

 
affymetrix
12-5986-82
100μg Each for $259.55
Description & Specifications

Specifications

Antigen CD273 (B7-DC)
Clone TY25
Host Species Rat
Gene Alias B7DC, PD-L2, PDL-2, PDL2
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The TY25 monoclonal antibody reacts with mouse B7-DC/PD-L2. B7-DC, a member of the B7 family, has a predicted molecular weight of ∽25kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by sub-populations of dendritic cells, monocytes and macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, but binds PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. TY25 is a useful tool to study the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in mouse.