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CD273 (B7-DC) Mouse anti-Human, Biotin, Clone: MIH18, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $288.55

Specifications

Antigen CD273 (B7-DC)
Clone MIH18
Host Species Mouse
Gene Alias B7DC, PDCD1LG2, Btdc, PDL2, PD-L2, PDCD1L2
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011997

 
affymetrix
13-5888-80
25μg Each for $129.05

501128750

 
affymetrix
13-5888-82
100μg Each for $288.55
Description & Specifications

Specifications

Antigen CD273 (B7-DC)
Clone MIH18
Host Species Mouse
Gene Alias B7DC, PDCD1LG2, Btdc, PDL2, PD-L2, PDCD1L2
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Biotin
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The MIH18 monoclonal antibody reacts with human B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25kDa and belongs to the Ig superfamily. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. MIH18 is a useful tool for studies to elucidate the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in humans. MIH18 is a blocking antibody.