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CD270 (HVEM) Armenian Hamster anti-Mouse, Clone: LH1, eBioscience™

Armenian Hamster Monoclonal Antibody

$129.05 - $361.05

Specifications

Antigen CD270 (HVEM)
Clone LH1
Host Species Armenian Hamster
Gene Alias herpes virus entry mediator, TNFRSF14, LIGHTR
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013370

 
affymetrix
14-5962-80
25μg Each for $129.05

5013371

 
affymetrix
14596282
100μg Each for $361.05
Description & Specifications

Specifications

Antigen CD270 (HVEM)
Clone LH1
Host Species Armenian Hamster
Gene Alias herpes virus entry mediator, TNFRSF14, LIGHTR
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The LH1 monoclonal antibody reacts with mouse Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is found on most cell types, including T cells, B cells, monocytes, neutrophils and dendritic cells. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of HVEM was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. HVEM has also been demonstrated to be a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response. The LH1 antibody has been reported as a blocking antibody, interfering with the HVEM-LIGHT interaction but not the HVEM-BTLA interaction.