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CD266 (TWEAK Receptor) Mouse anti-Human, Mouse, Clone: ITEM-4, eBioscience™

Mouse Monoclonal Antibody

$143.88 - $302.28

Specifications

Antigen CD266 (TWEAK Receptor)
Clone ITEM-4
Host Species Murine
Gene Alias TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
Applications Flow Cytometry,Immunohistochemistry (Frozen),Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122748 Life Technologies
LS14901882
100μg Each for $302.28
5013772 Life Technologies
LS14901880
25μg Each for $143.88
Specifications

Description

The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. It has been reported that ITEM-4 cross-reacts with mouse Fn14. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line.
The ITEM-4 antibody has been show to have blocking function.
Description & Specifications

Specifications

CD266 (TWEAK Receptor)
Murine
Flow Cytometry,Immunohistochemistry (Frozen),Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
ITEM-4
TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer