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CD266 (TWEAK Receptor) Mouse anti-Human, Mouse, Clone: ITEM-4, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $332.05

Specifications

Antigen CD266 (TWEAK Receptor)
Clone ITEM-4
Host Species Mouse
Gene Alias TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
Species Reactivity Human, Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122748

 
affymetrix
14901882
100μg Each for $332.05

5013772

 
affymetrix
14-9018-80
25μg Each for $158.05
Description & Specifications

Specifications

Antigen CD266 (TWEAK Receptor)
Clone ITEM-4
Host Species Mouse
Gene Alias TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
Species Reactivity Human, Mouse
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. It has been reported that ITEM-4 cross-reacts with mouse Fn14. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line.
The ITEM-4 antibody has been show to have blocking function.