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CD266 (TWEAK Receptor) Mouse anti-Human, Clone: ITEM-1, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $332.05

Specifications

Antigen CD266 (TWEAK Receptor)
Clone ITEM-1
Host Species Mouse
Gene Alias TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122749

 
affymetrix
14901982
100μg Each for $332.05

5013774

 
affymetrix
14-9019-80
25μg Each for $158.05
Description & Specifications

Specifications

Antigen CD266 (TWEAK Receptor)
Clone ITEM-1
Host Species Mouse
Gene Alias TNFRSF12A, TWEAKR, Fibroblast growth factor-inducible 14, Fn14
Species Reactivity Human
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.