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CD265 (RANK) Rat anti-Mouse, PE, Clone: R12-31, eBioscience™

Rat Monoclonal Antibody

$187.05 - $332.05

Specifications

Antigen CD265 (RANK)
Clone R12-31
Host Species Rat
Gene Alias Receptor Activator of NF-kB
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011094

 
affymetrix
12-6612-81
50μg Each for $187.05

501122369

 
affymetrix
12661282
100μg Each for $332.05
Description & Specifications

Specifications

Antigen CD265 (RANK)
Clone R12-31
Host Species Rat
Gene Alias Receptor Activator of NF-kB
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The R12-31 monoclonal antibody reacts with mouse RANK (Receptor activator of NF-κB), a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-κB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-κB, whereas JNK activation is mediated through binding of RANK to TRAF2.