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CD26 Rat anti-Mouse, PerCP-Cy5.5, Clone: H194-112 (H194-112.12.4.4.5), eBioscience™

Rat Monoclonal Antibody

$172.55 - $433.55

Specifications

Antigen CD26
Clone H194-112 (H194-112.12.4.4.5)
Host Species Rat
Gene Alias Dipeptidyl Peptidase IV, DPPIV, DPP4,
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015784

 
affymetrix
45-0261-80
25μg Each for $172.55

5015785

 
affymetrix
45026182
100μg Each for $433.55
Description & Specifications

Specifications

Antigen CD26
Clone H194-112 (H194-112.12.4.4.5)
Host Species Rat
Gene Alias Dipeptidyl Peptidase IV, DPPIV, DPP4,
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PerCP-Cy5.5
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody H194-112 recognizes mouse CD26, a thymocyte-activating molecule (THAM). CD26 is a surface expressed and soluble ectoenzyme (dipeptidyl peptidase IV) that cleaves dipeptides from the amino terminus of proteins. In particular CD26 has been shown to cleave CXCL12, CCL22, neuropeptide Y and glucagon. CD26 is involved in adhesion, apoptosis, disease regulation, and engraftment. Expression is regulated during thymic development at the messenger RNA level. Additionally, CD26 protein is found on thymocytes, a percentage of resting B cells, stimulated B cells, NK cells and a percentage of resting and activated T cells and other epithelial cell types. On human cells more CD26 protein is found on Th2 cells. Functional CD26 is expressed on Sca-1+c-Kit+lin- cells. This expression has been shown to correlate with mobilization of progenitor cells. Inhibition of CD26 activity through a variety of compounds enhances allogenic stem cell homing and engraftment.

This antibody is reported to have activating function.