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CD257 (BAFF, BLyS) Mouse anti-Human, PE, Clone: 1D6, eBioscience™

Mouse Monoclonal Antibody

$183.48 - $394.68

Specifications

Antigen CD257 (BAFF, BLyS)
Clone 1D6
Host Species Murine
Gene Alias TNFSF13B, BLYS, TALL-1, TALL1, THANK
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5011234 Life Technologies
LS12901741
25 Tests Each for $183.48
5011235 Life Technologies
LS12901742
100 Tests Each for $394.68
Specifications

Description

The 1D6 monoclonal antibody reacts with human BLyS (B lymphocyte stimulator), also known as BAFF (B cell activating factor from the TNF family), TALL-1 (TNF and apoptosis leukocyte-expressed ligand-1), THANK (TNF homologue that activates apoptosis, nuclear factor KappaB and c-Jun NH2-terminal kinase) and zTNF4. BLyS, a member of the TNF family, is a type II membrane protein that exists in both membrane-bound and soluble forms. Expression of membrane-bound BLyS on monocytes lineage is regulated by IFN gamma. BLyS acts as a potent B cell growth factor and costimulator of Ig production. BLyS transgenic mice develop severe B cell hyperplasia and autoimmune lupus-like disease characterized by the presence of autoantibodies against nuclear antigens and immune complexes deposited in the kidney. Data from animal models imply a role for BLyS in human autoimmune diseases. To date BCMA, TACI and BR3 have been identified as receptors for BLyS. APRIL, another TNF family member, and BLyS can form active heterotrimeric molecules when coexpressed and these circulating heterotrimers are present in serum samples from patients with systemic immune-based rheumatic diseases. Furthermore, it has been reported that BLyS and APRIL, share BCMA and TACI as their receptors.
Description & Specifications

Specifications

CD257 (BAFF, BLyS)
Murine
Flow Cytometry
PE
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.5μg)/test
1D6
TNFSF13B, BLYS, TALL-1, TALL1, THANK
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer