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CD254 (RANK Ligand) Rat anti-Mouse, PE, Clone: IK22/5, eBioscience™

Rat Monoclonal Antibody

$216.05 - $274.05

Specifications

Antigen CD254 (RANK Ligand)
Clone IK22/5
Host Species Rat
Gene Alias OPGL, TNFSF11, ODF
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011013

 
affymetrix
12-5952-81
50μg Each for $216.05

501122360

 
affymetrix
12595282
100μg Each for $274.05
Description & Specifications

Specifications

Antigen CD254 (RANK Ligand)
Clone IK22/5
Host Species Rat
Gene Alias OPGL, TNFSF11, ODF
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The IK22/5 monoclonal antibody reacts with mouse CD254 also known as TRANCE (TNF-related activation-induced cytokine receptor) and RANKL (receptor activator of NF-kappa B ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation and is expressed abundantly by mouse T cells not B cells in mouse thymus and lymph nodes. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.