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CD25 Rat anti-Mouse, Alexa Fluor 488, Clone: 7D4, eBioscience™

Rat Monoclonal Antibody

$129.05 - $288.55

Specifications

Antigen CD25
Clone eBio7D4 (7D4)
Host Species Rat
Gene Alias Interleukin-2 Receptor alpha
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5016694

 
affymetrix
53025280
25μg Each for $129.05

5016695

 
affymetrix
53025282
100μg Each for $288.55
Description & Specifications

Specifications

Antigen CD25
Clone eBio7D4 (7D4)
Host Species Rat
Gene Alias Interleukin-2 Receptor alpha
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Alexa Fluor 488
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The eBio7D4 antibody reacts with mouse CD25, the 55kDa interleukin-2 receptor a chain (IL-2Ra). CD25 is expressed by early progenitors of the T and B lineage, as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 only with low affinity. However, CD25 associates with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) to form the high affinity IL-2 receptor. CD25 plays a role in lymphocyte differentiation and activation/proliferation. The epitopes recognized by eBio3C7, PC61.5 and eBio7D4 are all different allowing for depletion with one antibody (typically PC61.5) followed by subsequent detection with another one. eBio7D4 has been reported to block IL-2 binding but can be overcome by additional IL-2. The monoclonal antibody PC61.5 (cat. 16-0251) is recommended for in vivo studies.