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CD244.1 Rat anti-Mouse, APC, Clone: C9.1, eBioscience™

Rat Monoclonal Antibody

$187.05 - $433.55

Specifications

Antigen CD244.1
Clone C9.1
Host Species Rat
Gene Alias 2B4, SLAMF4, NK cell type I receptor protein
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123111

 
affymetrix
17244080
25μg Each for $187.05

501123112

 
affymetrix
17244082
100μg Each for $433.55
Description & Specifications

Specifications

Antigen CD244.1
Clone C9.1
Host Species Rat
Gene Alias 2B4, SLAMF4, NK cell type I receptor protein
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody C9.1 reacts with mouse CD244.1. This receptor is expressed on NK cells, gamma delta T cells, some CD8+ T cells, basophils, and monocytes on most inbred mouse strains except C57BL/6 and C58, which express the CD244.2 allotype. CD244 is a CD2-related receptor belonging to the SLAM family that exists as two different isoforms with opposing functions. CD244 associates with CD48, which is expressed widely on hematopoietic cells, regulates NK cell proliferation, cytotoxicity, and cytokine production. However, the CD244/CD28 interaction between NK and other cell types inhibits NK cytotoxicity, which contributes to self-tolerance. CD244 may enhance or inhibit CD8+ T cell effector function depending on SAP levels.

The C9.1 antibody has been reported to have antagonist activity on activated NK cells.