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The C9.1 antibody has been reported to have antagonist activity on activated NK cells.Description & Specifications
DescriptionThe monoclonal antibody C9.1 reacts with mouse CD244.1. This receptor is expressed on NK cells, gamma delta T cells, some CD8+ T cells, basophils, and monocytes on most inbred mouse strains except C57BL/6 and C58, which express the CD244.2 allotype. CD244 is a CD2-related receptor belonging to the SLAM family that exists as two different isoforms with opposing functions. CD244 associates with CD48, which is expressed widely on hematopoietic cells, regulates NK cell proliferation, cytotoxicity, and cytokine production. However, the CD244/CD28 interaction between NK and other cell types inhibits NK cytotoxicity, which contributes to self-tolerance. CD244 may enhance or inhibit CD8+ T cell effector function depending on SAP levels.
The C9.1 antibody has been reported to have antagonist activity on activated NK cells.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|2B4, SLAMF4, NK cell type I receptor protein|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|