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CD243 (ABCB1) Mouse anti-Human, FITC, Clone: UIC2, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $404.55

Specifications

Antigen CD243 (ABCB1)
Clone UIC2
Host Species Mouse
Gene Alias P-glycoprotein-1, MDR1
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122110

 
affymetrix
11243941
25 tests Each for $158.05

501122111

 
affymetrix
11243942
100 tests Each for $404.55
Description & Specifications

Specifications

Antigen CD243 (ABCB1)
Clone UIC2
Host Species Mouse
Gene Alias P-glycoprotein-1, MDR1
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate FITC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test

This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A 170kDa transmembrane protein, MDR-1 is an ATP-dependent efflux pump for lipophilic compounds, including anti-cancer drugs. Expression of MDR-1 has been shown to correlate with multidrug resistance. In fact, tumor resistance to chemotherapy has been linked to MDR-1 expression in many cancers. MDR-1 is expressed in a variety of tissues, including the brain, kidney, liver, pancreas, and testes. Within the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes.

This antibody has been reported to inhibit MDR1-mediated efflux.