Please login to your online account to display your discounted pricing

CD230 (PrP) Mouse anti-Human, Clone: 4D5, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $230.55

Specifications

Antigen CD230 (PrP)
Clone 4D5
Host Species Mouse
Gene Alias Prion protein
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013811

 
affymetrix
14923080
25μg Each for $129.05

5013812

 
affymetrix
14923082
100μg Each for $230.55
Description & Specifications

Specifications

Antigen CD230 (PrP)
Clone 4D5
Host Species Mouse
Gene Alias Prion protein
Species Reactivity Human
Applications Flow Cytometry
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

CD230 (prion protein; PrPC) is a 35 kD glycoprotein, attached to the cell surface via a GPI-anchor. While the function of CD230 is unclear, prion protein has been the focus of research based on its involvement in transmissible spongiform encephalopathies (TSE), including Creutzfeld-Jakob disease in humans. CD230 undergoes a conformational change in which the cellular PrPC form is converted to the scrapie PrPSc form. This conversion is essential for the infectiousness of prion-based diseases. CD230 is predominantly expressed on the surface of lymphocytes and monocytes, with weak expression on granulocytes and erythrocytes. In platelets, CD230 is expressed primarily intracellularly, and is upregulated to the surface upon activation.