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CD230 (PrP) Mouse anti-Human, Clone: 4D5, eBioscience™

Mouse Monoclonal Antibody

$117.48 - $209.88

Specifications

Antigen CD230 (PrP)
Clone 4D5
Host Species Murine
Gene Alias Prion protein
Applications Flow Cytometry,Immunoprecipitation,Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013811 Life Technologies
LS14923080
25μg Each for $117.48
5013812 Life Technologies
LS14923082
100μg Each for $209.88
Specifications

Description

CD230 (prion protein; PrPC) is a 35 kD glycoprotein, attached to the cell surface via a GPI-anchor. While the function of CD230 is unclear, prion protein has been the focus of research based on its involvement in transmissible spongiform encephalopathies (TSE), including Creutzfeld-Jakob disease in humans. CD230 undergoes a conformational change in which the cellular PrPC form is converted to the scrapie PrPSc form. This conversion is essential for the infectiousness of prion-based diseases. CD230 is predominantly expressed on the surface of lymphocytes and monocytes, with weak expression on granulocytes and erythrocytes. In platelets, CD230 is expressed primarily intracellularly, and is upregulated to the surface upon activation.
Description & Specifications

Specifications

CD230 (PrP)
Murine
Flow Cytometry,Immunoprecipitation,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
4D5
Prion protein
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer