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CD227 (Mucin-1) Mouse anti-Human, Alexa Fluor 488, Clone: SM3, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $477.05

Specifications

Antigen CD227 (Mucin-1)
Clone SM3
Host Species Mouse
Gene Alias Mucin Glycoprotein, MUC1, EMA (Epithelial Membrane Antigen), Episialin, Tumor-Associated Mucin, PEM (Polymorphic Epithelial Mucin), Breast Cancer-Associated Antigen
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5016834

 
affymetrix
53-9893-80
25μg Each for $172.55

5016835

 
affymetrix
53989382
100μg Each for $477.05
Description & Specifications

Specifications

Antigen CD227 (Mucin-1)
Clone SM3
Host Species Mouse
Gene Alias Mucin Glycoprotein, MUC1, EMA (Epithelial Membrane Antigen), Episialin, Tumor-Associated Mucin, PEM (Polymorphic Epithelial Mucin), Breast Cancer-Associated Antigen
Species Reactivity Human
Applications Flow Cytometry
Applications Immunocytochemistry
Regulatory Status RUO
Conjugate Alexa Fluor 488
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This SM3 monoclonal antibody reacts with the under-glycosylated form of human Mucin 1 (MUC1, CD227), a large glycoprotein belonging to the mucin protein family. Mucin 1 contains a polypeptide core consisting of multiple tandem repeats that become highly glycosylated. Mucin 1 is typically expressed in ductal or glandular epithelial cells and is localized to the apical membrane. In cancerous cells, Mucin 1 expression is increased and membrane-specific localization is lost resulting in expression throughout the membrane and cytoplasm. High levels of under-glycosylated Mucin 1 are thought to affect cell behavior during both invasion and metastasis as well as in immune recognition. In addition, under-glycosylated Mucin 1 is shed from the epithelial cell surface and can be detected in circulation. Alterations in Mucin 1 glycosylation are found in most adenocarcinomas of the breast, lung, pancreas, prostate, and ovary. Mucin 1 has recently been shown to co-localize and interact with members of the erbB receptor kinase family, proteins that are upregulated in more aggressive forms of breast cancer.
Please note this antibody sees a distinct epitope from other Mucin 1 antibodies.